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Article

Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2016

Mengel-From Jonas, Soerensen Mette, Nygaard Marianne, McGue Matt, Christensen Kaare, Christiansen Lene

Abstract excerpt

Decline in cognitive abilities is a major concern in aging individuals. A potential important factor for functioning of the central nervous system in late-life stages is the KLOTHO (KL) gene. KL is expressed in various organs including the brain and is involved in multiple biological processes, for example, growth factor signaling. In the present study, 19 tagging gene variants in KL were studied in relation to 2...

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Identifiers

PMID: 26405063
DOI: 10.1093/gerona/glv163
PMCID: PMC4978356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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