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Article

Longevity Klotho gene polymorphism and the risk of dementia in older men.

Maturitas - 1 Jul 2017

Almeida Osvaldo P, Morar Bharti, Hankey Graeme J, Yeap Bu B, Golledge Jonathan, Jablensky Assen, Flicker Leon

Abstract excerpt

INTRODUCTION: Klotho variants (KL-VS) have been associated with increased longevity and better cognitive function. It is unclear whether they modulate dementia risk. METHODS: We recruited 527 men aged 71-87 years who were free of cognitive impairment. We used data linkage to track the onset of dementia over 10 years. KL-VS genotyping (rs9536314 T/G) followed standard procedures. RESULTS: The annual rate of...

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Cognition
Aged, 80 and over
Dementia
Glucuronidase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Klotho Proteins

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PMID: 28539162
DOI: 10.1016/j.maturitas.2017.04.005

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