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Is there association between <i>APOE</i> e4 genotype and structural brain ageing phenotypes, and does that association increase in older age in UK Biobank? (N = 8,395)

2017-12-08

Abstract excerpt

Apolipoprotein ( APOE ) e4 genotype is a purported risk factor for accelerated cognitive ageing and dementia, though its neurostructural substrates are unclear. The deleterious effects of this genotype on brain structure may increase in magnitude into older age. This study aimed to investigate in UK Biobank the association between APOE e4 allele presence vs. absence and brain imaging variables that have been ass...

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Literature Corpus work
7e571531-4866-5a78-bb50-7c98295153f9
DOI
10.1101/230524
Open publication

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