Article

Leveraging large multi-center cohorts of Alzheimer Disease endophenotypes to understand the role of Klotho heterozygosity on disease risk

2021-10-10

Abstract excerpt

Two genetic variants (rs9536314 and rs9527025) in the Klotho gene, encoding a transmembrane protein, implicated on longevity and associated with brain resilience during normal aging, were recently shown to be associated with Alzheimer disease (AD) risk in cognitively healthy individuals that are APOE4 carriers. Specifically, the individuals heterozygous for this variant (KL-SV HET+ ), showed lower risk of developi...

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Literature Corpus work: c94bd8de-8bd0-57de-bbba-9d7030cf18a1
DOI: 10.1101/2021.10.07.21264646

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