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Article

Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4.

JAMA neurology - 1 Jul 2020

Belloy Michael E, Napolioni Valerio, Han Summer S, Le Guen Yann, Greicius Michael D

Abstract excerpt

Importance: Identification of genetic factors that interact with the apolipoprotein e4 (APOE4) allele to reduce risk for Alzheimer disease (AD) would accelerate the search for new AD drug targets. Klotho-VS heterozygosity (KL-VSHET+ status) protects against aging-associated phenotypes and cognitive decline, but whether it protects individuals who carry APOE4 from AD remains unclear. Objectives: To determine if...

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Alzheimer Disease
Amyloid beta-Peptides
Apolipoprotein E4
Brain
Cognitive Dysfunction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Disease Progression

Klotho Proteins

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Identifiers

PMID: 32282020
DOI: 10.1001/jamaneurol.2020.0414
PMCID: PMC7154955

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Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4.PMID 32282020Read ↗

KLOTHO heterozygosity attenuates APOE4 -related amyloid burden in preclinical ADSemantic proximity Read ↗

Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau BurdenSemantic proximity Read ↗

Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease.Semantic proximity Read ↗

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Leveraging large multi-center cohorts of Alzheimer Disease endophenotypes to understand the role of Klotho heterozygosity on disease riskSemantic proximity Read ↗

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Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease.Semantic proximity Read ↗

KLOTHO KL‐VS heterozygosity is associated with diminished age‐related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adultsSemantic proximity Read ↗

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