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Article

Alzheimer disease genetic risk factor APOE e4 and cognitive abilities in 111,739 UK Biobank participants.

Age and ageing - 1 Jul 2016

Lyall Donald M, Ward Joey, Ritchie Stuart J, Davies Gail, Cullen Breda, Celis Carlos, Bailey Mark E S, Anderson Jana, Evans Jon, Mckay Daniel F, Mcintosh Andrew M, Sattar Naveed, Smith Daniel J, Deary Ian J, Pell Jill P

Abstract excerpt

BACKGROUND: the apolipoprotein (APOE) e4 locus is a genetic risk factor for dementia. Carriers of the e4 allele may be more vulnerable to conditions that are independent risk factors for cognitive decline, such as cardiometabolic diseases. OBJECTIVE: we tested whether any association with APOE e4 status on cognitive ability was larger in older ages or in those with cardiometabolic diseases. SUBJECTS: UK Biobank...

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Identifiers

PMID: 27103599
DOI: 10.1093/ageing/afw068

Genes

APOE
CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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