Article
Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging.
Brain imaging and behavior - 1 Apr 2017
Yokoyama Jennifer S, Marx Gabe, Brown Jesse A, Bonham Luke W, Wang Dan, Coppola Giovanni, Seeley William W, Rosen Howard J, Miller Bruce L, Kramer Joel H, Dubal Dena B
Abstract excerpt
Cognitive decline is a major biomedical challenge as the global population ages. Elevated levels of the longevity factor klotho suppress aging, enhance cognition, and promote synaptic plasticity and neural resilience against aging and Alzheimer's disease (AD)-related pathogenic proteins. Here, we examined the relationship between human genetic variants of KLOTHO and systemic klotho levels - and assessed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.