Article

Associations of<i>APOE</i>e2/e4 dosage and lifestyle on neuroimaging markers in the UK Biobank

2025-05-13

Abstract excerpt

<h4>Background</h4> Variation in the Apolipoprotein E (APOE) gene is a key genetic determinant of Alzheimer’s disease (AD) risk and is associated with AD-related neuroimaging changes. Lifestyle factors are also associated with AD risk and may interact with APOE to influence neuroimaging biomarkers. However, evidence on these interactions remains limited and inconsistent, particularly regarding composite healthy li...

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Literature Corpus work: ef9d623e-d8c9-5f08-aaf1-d4b317c38be0
DOI: 10.1101/2025.05.12.25327420

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