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A Human iPSC-Derived Tri-Culture Model of NeuroHIV: HIV Infection, Antiretroviral Drug Effects, Microglial Morphology, and Neuronal Calcium Dynamics

2026-08-14

Abstract excerpt

HIV-associated neurocognitive disorders (HAND) involve persistent central nervous system (CNS) viral reservoirs in microglia, driving chronic neuroinflammation, synaptic dysfunction, and neuronal injury. Thus, scalable, human-relevant multicellular CNS models are needed to elucidate neuroHIV pathogenesis and ART neurotoxicity. Here, we establish and characterize a fully human iPSC-derived (hiPSC) CNS tri-culture p...

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Literature Corpus work
b1bf783a-05ce-5556-b13d-5720dd93d74b
DOI
10.20944/preprints202608.1008.v1
Open publication

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