Article

Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain Regions

2025-02-08

Abstract excerpt

HIV infection exerts profound and long-lasting neurodegenerative effects on the central nervous system (CNS) that can persist despite antiretroviral therapy (ART). Here, we used single-nucleus multiome sequencing to map the transcriptomic and epigenetic landscapes of postmortem human brains from 13 healthy individuals and 20 individuals with HIV who have a history of treatment with ART. Our study spanned three dis...

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Literature Corpus work: 0ad1d22d-5f34-5725-869b-fabab6db4a71
DOI: 10.1101/2025.02.05.636707

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