Back to search

Article

STAT1-Mediated Regulation of IL-17A/CEBPB/NF-κB Axis in HIV-1 Infected Human Cerebral Organoids Reveals Therapeutic Targets for Neuroprotection

2025-12-31

Abstract excerpt

HIV-associated neurological complications remain a major concern in people living with HIV (PLWH), even under effective viral suppression with combination antiretroviral therapy (cART), underscoring unresolved mechanisms driving HIV-related neurodegeneration. To address this gap, we used HIV-1–infected human cerebral organoids (hCOs) containing microglia as a physiologically relevant three-dimensional model of the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f3495d20-ac5c-51d3-8749-4f58e7ea797d
DOI
10.64898/2025.12.30.697044
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
STAT1-Mediated Regulation of IL-17A/CEBPB/NF-κB Axis in HIV-1 Infected Human Cerebral Organoids Reveals Therapeutic Targets for NeuroprotectionDOI 10.64898/2025.12.30.697044
Transcriptional Mapping of Neuro-Immune Interactions during Homeostasis and HIV infection using Microglia-containing Human Cerebral AssembloidsSemantic proximity
Human microglial models to study HIV infection and neuropathogenesis: a literature overview and comparative analysesSemantic proximity
Dysregulated neuroimmune interactions and sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoidsSemantic proximity
Multi-omic Characterization of HIV Effects at Single Cell Level across Human Brain RegionsSemantic proximity
HIV-1 infection of human microglia activates inflammatory pathways associated with HIV-associated neurocognitive disorders (HAND)Semantic proximity
HIV-1 infection promotes neuroinflammation and neuron pathogenesis in novel microglia-containing cerebral organoidsSemantic proximity
Neuroinflammation and EIF2 signaling persist in an HiPSC tri-culture model of HIV infection despite antiretroviral treatmentSemantic proximity
Human microglia phenotypes in the brain associated with HIV infection.Semantic proximity
Single cell RNA sequencing reveals a novel, microglia-like cell type in cerebrospinal fluid during virologically suppressed HIVSemantic proximity
Modeling HIV-1 infection and NeuroHIV in hiPSCs-derived cerebral organoid culturesSemantic proximity
A Human iPSC-Derived Tri-Culture Model of NeuroHIV: HIV Infection, Antiretroviral Drug Effects, Microglial Morphology, and Neuronal Calcium DynamicsSemantic proximity
Investigation of CNS damage following HIV infection and methamphetamine exposure using human iPSC-derived microglia and 3D cerebral assembloid modelsSemantic proximity
Select a neighboring publication to make it the new centre.