Article

Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated state

2021-10-26

Abstract excerpt

In humans, there are three paralogs of the Orai Ca 2+ channel, which lie at the heart of the store-operated calcium entry (SOCE) machinery. While the STIM-mediated gating mechanism of Orai channels is still being actively investigated, several artificial and natural variants are known to cause constitutive activity of the human Orai1 channel. Surprisingly, little is known about the conservation of the gating mech...

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Literature Corpus work: b1898968-6e34-5ed0-a909-f6992a78d4bd
DOI: 10.1101/2021.10.26.465861

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