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Article

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels.

The Journal of cell biology - 8 Jun 2015

Rana Anshul, Yen Michelle, Sadaghiani Amir Masoud, Malmersjö Seth, Park Chan Young, Dolmetsch Ricardo E, Lewis Richard S

Abstract excerpt

Store-operated calcium entry (SOCE) regulates a wide variety of essential cellular functions. SOCE is mediated by STIM1 and STIM2, which sense depletion of ER Ca(2+) stores and activate Orai channels in the plasma membrane. Although the amplitude and dynamics of SOCE are considered important determinants of Ca(2+)-dependent responses, the underlying modulatory mechanisms are unclear. In this paper, we identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26033257
DOI: 10.1083/jcb.201412060
PMCID: PMC4460148

Genes

STIM2
STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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