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Article

Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.

Science signaling - 19 Mar 2013

Rothberg Brad S, Wang Youjun, Gill Donald L

Abstract excerpt

The Orai channels are unusual, yet prominent, calcium (Ca2+) signal mediators in most cell types. Orai proteins are structurally unique, having little sequence homology with other ion channels. They are also functionally unique with exceedingly high selectivity for Ca2+, mediating both short-term Ca2+ homeostasis and long-term Ca2+ signals important for transcriptional control. Operating in the plasma membrane...

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Share to Calcium Channels
Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23512988
DOI: 10.1126/scisignal.2003971
PMCID: PMC4746713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.PMID 23512988Read ↗

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Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels.Semantic proximity Read ↗

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.Semantic proximity Read ↗

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.Semantic proximity Read ↗

SOAR and the polybasic STIM1 domains gate and regulate Orai channels.Semantic proximity Read ↗

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