Article

A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription

2026-07-13

Abstract excerpt

The Ca²⁺ release-activated Ca²⁺ (CRAC) channel mediates store-operated calcium entry (SOCE), a ubiquitous pathway essential for many cell types, including immune cells. Three Orai (Orai1/2/3) proteins constitute the plasma membrane pore-forming units of CRAC channels that are activated by the endoplasmic reticulum (ER) Ca 2+ -sensing STIM1/2 proteins when ER Ca 2+ stores are depleted. Orai1/2/3 are differentiall...

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Literature Corpus work: 90a7c129-abe4-5628-9dff-8021b43c7f37
DOI: 10.64898/2026.07.10.737753

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