Orais and STIMs: physiological mechanisms and disease.

doi:10.1111/j.1582-4934.2011.01395.x

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Article

Orais and STIMs: physiological mechanisms and disease.

Journal of cellular and molecular medicine - 1 Mar 2012

Berna-Erro A, Woodard G E, Rosado J A

Abstract excerpt

The stromal interaction molecules STIM1 and STIM2 are Ca(2+) sensors, mostly located in the endoplasmic reticulum, that detect changes in the intraluminal Ca(2+) concentration and communicate this information to plasma membrane store-operated channels, including members of the Orai family, thus mediating store-operated Ca(2+) entry (SOCE). Orai and STIM proteins are almost ubiquitously expressed in human...

Topics

Animals
Autoimmune Diseases
Calcium
Calcium Channels
Calcium Signaling
Cell Adhesion Molecules
Cell Membrane
Drosophila melanogaster
Endoplasmic Reticulum
Humans
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Neoplasm Proteins

ORAI1 Protein

Stromal Interaction Molecule 1

Stromal Interaction Molecule 2

Source

Open in PubMed Open full text

Identifiers

PMID: 21790973
DOI: 10.1111/j.1582-4934.2011.01395.x
PMCID: PMC3822919

Genes

STIM1
STIM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Orais and STIMs: physiological mechanisms and disease.PMID 21790973Read ↗

The Ca2+ Sensor STIM in Human Diseases.Semantic proximity Read ↗

A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiencySemantic proximity Read ↗

Diseases caused by mutations in ORAI1 and STIM1.Semantic proximity Read ↗

Immunodeficiency due to mutations in ORAI1 and STIM1.Semantic proximity Read ↗

STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror DiseasesSemantic proximity Read ↗

STIM and ORAI proteins: crucial roles in hallmarks of cancerSemantic proximity Read ↗

[Immunodeficiencies and pathologies associated with mutations in STIM/ORAI, a membrane complex in the heart of calcium signalling].Semantic proximity Read ↗

STIM1 over-activation generates a multi-systemic phenotype affecting the skeletal muscle, spleen, eye, skin, bones and immune system in miceSemantic proximity Read ↗

Physiological and pathophysiological functions of SOCE in the immune system.Semantic proximity Read ↗

A novel bi-allelic loss-of-function mutation in STIM1 expands the phenotype of STIM1-related diseases.Semantic proximity Read ↗

Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.Semantic proximity Read ↗

Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity.Semantic proximity Read ↗

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