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Article

Gated regulation of CRAC channel ion selectivity by STIM1.

Nature - 25 Jan 2012

McNally Beth A, Somasundaram Agila, Yamashita Megumi, Prakriya Murali

Abstract excerpt

Two defining functional features of ion channels are ion selectivity and channel gating. Ion selectivity is generally considered an immutable property of the open channel structure, whereas gating involves transitions between open and closed channel states, typically without changes in ion selectivity. In store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels, the molecular mechanism of channel gating by...

Topics

Calcium Channels
HEK293 Cells
Humans
Ion Channel Gating
Membrane Proteins
Models, Molecular
Mutation
Neoplasm Proteins
ORAI1 Protein
Stromal Interaction Molecule 1
Structure-Activity Relationship

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 22278058
DOI: 10.1038/nature10752
PMCID: PMC3276717

Genes

STIM1
ORAI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Gated regulation of CRAC channel ion selectivity by STIM1.PMID 22278058Read ↗

Review: Structure and Activation Mechanisms of CRAC Channels.Semantic proximity Read ↗

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

Orai1 is an essential pore subunit of the CRAC channel.Semantic proximity Read ↗

Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits.Semantic proximity Read ↗

CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.Semantic proximity Read ↗

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels.Semantic proximity Read ↗

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.Semantic proximity Read ↗

Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.Semantic proximity Read ↗

A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.Semantic proximity Read ↗

The action of selective CRAC channel blockers is affected by the Orai pore geometry.Semantic proximity Read ↗

Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai.Semantic proximity Read ↗

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