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Article

Activation of STIM1-Orai1 involves an intramolecular switching mechanism.

Science signaling - 16 Nov 2010

Korzeniowski Marek K, Manjarrés Isabel Martín, Varnai Peter, Balla Tamas

Abstract excerpt

Stromal interaction molecule 1 (STIM1) stimulates calcium ion (Ca(2+)) entry through plasma membrane Orai1 channels in response to decreased Ca(2+) concentrations in the endoplasmic reticulum lumen. We identified an acidic motif within the STIM1 coiled-coil region that keeps its Ca(2+) activation domain [Ca(2+) release-activated Ca(2+) (CRAC) activation domain/STIM1-Orai activating region (CAD/SOAR)]-a...

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Source

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Identifiers

PMID: 21081754
DOI: 10.1126/scisignal.2001122
PMCID: PMC3408607

Genes

STIM1
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Activation of STIM1-Orai1 involves an intramolecular switching mechanism.PMID 21081754Read ↗

Intramolecular shielding maintains the ER Ca²⁺ sensor STIM1 in an inactive conformation.Semantic proximity Read ↗

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SOAR and the polybasic STIM1 domains gate and regulate Orai channels.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels.Semantic proximity Read ↗

Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.Semantic proximity Read ↗

Sequential activation of STIM1 links Ca2+ with luminal domain unfolding.Semantic proximity Read ↗

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.Semantic proximity Read ↗

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