Article
Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologs.
Cell calcium - 1 Jul 2022
Augustynek Bartłomiej, Gyimesi Gergely, Dernič Jan, Sallinger Matthias, Albano Giuseppe, Klesse Gabriel J, Kandasamy Palanivel, Grabmayr Herwig, Frischauf Irene, Fuster Daniel G, Peinelt Christine, Hediger Matthias A, Bhardwaj Rajesh
Abstract excerpt
In humans, there are three paralogs of the Orai Ca2+ channel that form the core of the store-operated calcium entry (SOCE) machinery. While the STIM-mediated gating mechanism of Orai channels is still under active investigation, several artificial and natural variants are known to cause constitutive activity of the human Orai1 channel. Surprisingly, little is known about the conservation of the gating checkpoints...
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