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Article

The Ca2+ Sensor STIM in Human Diseases.

Biomolecules - 22 Aug 2023

Berna-Erro Alejandro, Sanchez-Collado Jose, Nieto-Felipe Joel, Macias-Diaz Alvaro, Redondo Pedro C, Smani Tarik, Lopez Jose J, Jardin Isaac, Rosado Juan A

Abstract excerpt

The STIM family of proteins plays a crucial role in a plethora of cellular functions through the regulation of store-operated Ca2+ entry (SOCE) and, thus, intracellular calcium homeostasis. The two members of the mammalian STIM family, STIM1 and STIM2, are transmembrane proteins that act as Ca2+ sensors in the endoplasmic reticulum (ER) and, upon Ca2+ store discharge, interact with and activate the Orai/CRACs in...

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Identifiers

PMID: 37759684
DOI: 10.3390/biom13091284
PMCID: PMC10526185

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The Ca2+ Sensor STIM in Human Diseases.PMID 37759684Read ↗

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