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Article

CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions.

The Journal of biological chemistry - 1 Jan 2000

Tiffner Adéla, Schober Romana, Höglinger Carmen, Bonhenry Daniel, Pandey Saurabh, Lunz Victoria, Sallinger Matthias, Frischauf Irene, Fahrner Marc, Lindinger Sonja, Maltan Lena, Berlansky Sascha, Stadlbauer Michael, Schindl Rainer, Ettrich Rudiger, Romanin Christoph, Derler Isabella

Abstract excerpt

The initial activation step in the gating of ubiquitously expressed Orai1 calcium (Ca2+) ion channels represents the activation of the Ca2+-sensor protein STIM1 upon Ca2+ store depletion of the endoplasmic reticulum. Previous studies using constitutively active Orai1 mutants gave rise to, but did not directly test, the hypothesis that STIM1-mediated Orai1 pore opening is accompanied by a global conformational...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33361160
DOI: 10.1074/jbc.RA120.015548
PMCID: PMC7948504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions.PMID 33361160Read ↗

Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologs.Semantic proximity Read ↗

A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels.Semantic proximity Read ↗

Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.Semantic proximity Read ↗

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.Semantic proximity Read ↗

A human tubular aggregate myopathy mutation unmasks STIM1-independent rapid inactivation of Orai1 channelsSemantic proximity Read ↗

Sequential Steps of CRAC Channel Activation.Semantic proximity Read ↗

Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated stateSemantic proximity Read ↗

Review: Structure and Activation Mechanisms of CRAC Channels.Semantic proximity Read ↗

Orai1 is an essential pore subunit of the CRAC channel.Semantic proximity Read ↗

Gated regulation of CRAC channel ion selectivity by STIM1.Semantic proximity Read ↗

Physiological CRAC channel activation and pore properties require STIM1 binding to all six Orai1 subunits.Semantic proximity Read ↗

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.Semantic proximity Read ↗

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