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Article

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.

Science signaling - 28 Nov 2017

Frischauf Irene, Litviňuková Monika, Schober Romana, Zayats Vasilina, Svobodová Barbora, Bonhenry Daniel, Lunz Victoria, Cappello Sabrina, Tociu Laura, Reha David, Stallinger Amrutha, Hochreiter Anna, Pammer Teresa, Butorac Carmen, Muik Martin, Groschner Klaus, Bogeski Ivan, Ettrich Rüdiger H, Romanin Christoph, Schindl Rainer

Abstract excerpt

The channel Orai1 requires Ca2+ store depletion in the endoplasmic reticulum and an interaction with the Ca2+ sensor STIM1 to mediate Ca2+ signaling. Alterations in Orai1-mediated Ca2+ influx have been linked to several pathological conditions including immunodeficiency, tubular myopathy, and cancer. We screened large-scale cancer genomics data sets for dysfunctional Orai1 mutants. Five of the identified Orai1...

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Identifiers

PMID: 29184031
DOI: 10.1126/scisignal.aao0358
PMCID: PMC6433236

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription.PMID 29184031Read ↗

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