Article

Convergent evolution between PALI1 and JARID2 for the allosteric activation of PRC2

2020-05-29

Abstract excerpt

<h4>ABSTRACT</h4> The polycomb repressive complex 2 (PRC2) is a histone methyltransferase that maintains cell identities. JARID2 is the only accessory subunit of PRC2 that known to trigger an allosteric activation of methyltransferase. Yet, this mechanism cannot be generalised to all PRC2 variants as, in vertebrates, JARID2 is mutually exclusive with most of the accessory subunits of PRC2. Here we provide functio...

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Literature Corpus work: b17ecfab-33ca-5a65-9557-23d47f48e82d
DOI: 10.1101/2020.05.28.122556

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