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Article

Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammals

2025-12-13

Abstract excerpt

The Polycomb Repressive Complex 2 (PRC2) is an ancient, conserved chromatin-interacting complex that controls gene expression, facilitating differentiation and cellular identity during development. Its regulation is critical in most eukaryotes. EZHIP was recently characterized as a PRC2 inhibitor and ‘oncohistone mimic’ in mammals. Although EZHIP expression is typically restricted to the germline, its aberrant ex...

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Literature Corpus work
137ea8dd-5ff7-535f-88a1-fe863b0d9f95
DOI
10.64898/2025.12.12.693809
Open publication

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Dynamic evolution of EZHIP, an inhibitor of the Polycomb Repressive Complex 2 in mammalsDOI 10.64898/2025.12.12.693809
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