Article

Diverse epigenomic mechanisms underpin transcriptional dysregulation in Polycomb-altered acute myeloid leukemia

2025-08-30

Abstract excerpt

<h4>Background</h4> Polycomb Repressive Complex 2 (PRC2) modulates chromatin accessibility and architecture to direct tissue-specific gene expression. PRC2 function is frequently altered in cancer by loss-of-function mutation or deletion, but the downstream effects on transcriptional regulation are incompletely understood. <h4>Results</h4> To gain insights into these mechanisms, we performed a holistic analysis...

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Literature Corpus work: 6932da79-51aa-50ca-91b1-a5a4fdc5459f
DOI: 10.1101/2025.08.28.672871

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