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Article

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.

Molecular cell - 5 Mar 2015

Sanulli Serena, Justin Neil, Teissandier Aurélie, Ancelin Katia, Portoso Manuela, Caron Matthieu, Michaud Audrey, Lombard Berangère, da Rocha Simao T, Offer John, Loew Damarys, Servant Nicolas, Wassef Michel, Burlina Fabienne, Gamblin Steve J, Heard Edith, Margueron Raphaël

Abstract excerpt

Polycomb Group (PcG) proteins maintain transcriptional repression throughout development, mostly by regulating chromatin structure. Polycomb Repressive Complex 2 (PRC2), a component of the Polycomb machinery, is responsible for the methylation of histone H3 lysine 27 (H3K27me2/3). Jarid2 was previously identified as a cofactor of PRC2, regulating PRC2 targeting to chromatin and its enzymatic activity. Deletion of...

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Chromatin
Embryonic Stem Cells
Enhancer of Zeste Homolog 2 Protein
Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycomb Repressive Complex 2

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PMID: 25620564
DOI: 10.1016/j.molcel.2014.12.020
PMCID: PMC4352895

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Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.PMID 25620564Read ↗

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