Article

AEBP2-Directed H3K27me2 Defines a Specific Vulnerability in EZH2-mutant Lymphoma

2025-10-15

Abstract excerpt

<h4>SUMMARY</h4> The catalytic subunit of Polycomb Repressive Complex 2 (PRC2), EZH2, is recurrently mutated in 25% of diffuse large B-cell lymphomas (DLBCL), causing increased H3K27me3 and decreased H3K27me2 levels. EZH2 inhibitors provide clinical benefit, but resistance frequently develops, highlighting the need for alternative therapeutic targets. Here, we identify the PRC2 accessory protein AEBP2 as a specif...

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Literature Corpus work: b4d1a176-79bc-5d6c-8ba6-048ad4b23f14
DOI: 10.1101/2025.10.14.682307

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