Article

PTE, a novel module to target Polycomb Repressive Complex 1 to the <i>Cyclin D2</i> oncogene

2017-08-16

Abstract excerpt

Polycomb Group proteins are essential epigenetic repressors. They form multiple protein complexes of which two kinds, PRC1 and PRC2, are indispensable for repression. Although much is known about their biochemical properties, how PRC1 and PRC2 are targeted to specific genes is poorly understood. Here we establish the Cyclin D2 ( CCND2 ) oncogene as a simple model to address this question. We provide the evidence...

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Literature Corpus work: abe8dbc2-822c-5a2e-bdf6-be97f8422774
DOI: 10.1101/177097

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