Article

JARID2 and AEBP2 regulate PRC2 activity in the presence of H2A ubiquitination or other histone modifications

2020-04-21

Abstract excerpt

<h4>ABSTRACT</h4> The Polycomb repressive complexes PRC1 and PRC2 functionally interact to coordinate cell type identity by the epigenetic regulation of gene expression. It has been proposed that PRC2 is recruited to genomic loci via the recognition of PRC1-mediated mono-ubiquitination of histone H2A at lysine 119 (H2AK119ub1), but the mechanism of this process remains poorly understood. Here, we report the cryo-...

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Literature Corpus work: 54410fe3-2cde-58a2-a6a7-47aeaf3a46a1
DOI: 10.1101/2020.04.20.049213

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