Article

Towards understanding the regulation of histone H1 somatic subtypes with OMICs

2020-10-02

Abstract excerpt

<h4>Background</h4> Histone H1 is involved in the regulation of chromatin higher-order structure and compaction. In humans, histone H1 is a multigene family with seven subtypes differentially expressed in somatic cells. Which are the regulatory mechanisms that determine the variability of the H1 complement is a long-standing biological question regarding histone H1. We have used a new approach based on the integr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 08f0c6ce-a748-5bcb-b3d0-0acf07f14a67
DOI: 10.1101/2020.09.30.320572

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Towards understanding the regulation of histone H1 somatic subtypes with OMICsDOI 10.1101/2020.09.30.320572Read

Imaging analysis of six human histone H1 variants reveals universal enrichment of H1.2, H1.3, and H1.5 at the nuclear periphery and nucleolar H1X presenceSemantic proximity Read

Large-scale determination and characterization of cell type-specific regulatory elements in the human genomeSemantic proximity Read

Coordinated changes in gene expression, H1 variant distribution and genome 3D conformation in response to H1 depletionSemantic proximity Read

Differential regulation of histone H1 subtypes by N6-methyladenosine RNA methylationSemantic proximity Read

Regulation associated modules reflect 3D genome modularity associated with chromatin activitySemantic proximity Read

Haystack: systematic analysis of the variation of epigenetic states and cell-type specific regulatory elementsSemantic proximity Read

A comprehensive catalog of 3D genome organization in diverse human genomes facilitates understanding of the impact of structural variation on chromatin structureSemantic proximity Read

Widespread variation in molecular interactions and regulatory properties among transcription factor isoformsSemantic proximity Read

Combined promoter-capture Hi-C and Hi-C analysis reveals a fine-tuned regulation of 3D chromatin architecture in colorectal cancerSemantic proximity Read

Aberrant expression of histone H2B variants reshape chromatin and alter oncogenic gene expression programsSemantic proximity Read

Intra- and inter-chromosomal chromatin interactions mediate genetic effects on regulatory networksSemantic proximity Read

The human canonical core histone catalogueSemantic proximity Read