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Article

Compositional and functional diversity of canonical PRC1 complexes in mammals.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Feb 2017

Connelly Katelyn E, Dykhuizen Emily C

Abstract excerpt

The compositional complexity of Polycomb Repressive Complex 1 (PRC1) increased dramatically during vertebrate evolution. What is considered the "canonical" PRC1 complex consists of four subunits originally identified as regulators of body segmentation in Drosophila. In mammals, each of these four canonical subunits consists of two to six paralogs that associate in a combinatorial manner to produce over a hundred...

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Identifiers

PMID: 28007606
DOI: 10.1016/j.bbagrm.2016.12.006

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PRC1

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