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Non-homologous end joining minimizes errors by coordinating DNA processing with ligation

2019-02-28

Abstract excerpt

Genome stability requires efficient and faithful repair of DNA double-strand breaks (DSBs). The predominant DSB repair pathway in human cells is non-homologous end-joining (NHEJ), which directly ligates DNA ends 1–5 . Broken DNA ends at DSBs are chemically diverse, and many are not compatible for direct ligation by the NHEJ-associated DNA Ligase IV (Lig4). To solve this problem, NHEJ end-processing enzymes includ...

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Literature Corpus work
b17cd857-61bc-52bd-96a1-583db5c495c2
DOI
10.1101/563197
Open publication

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Non-homologous end joining minimizes errors by coordinating DNA processing with ligationDOI 10.1101/563197
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