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Article

Repair of double-strand breaks by end joining.

Cold Spring Harbor perspectives in biology - 1 May 2013

Chiruvella Kishore K, Liang Zhuobin, Wilson Thomas E

Abstract excerpt

Nonhomologous end joining (NHEJ) refers to a set of genome maintenance pathways in which two DNA double-strand break (DSB) ends are (re)joined by apposition, processing, and ligation without the use of extended homology to guide repair. Canonical NHEJ (c-NHEJ) is a well-defined pathway with clear roles in protecting the integrity of chromosomes when DSBs arise. Recent advances have revealed much about the...

Topics

DNA Breaks, Double-Stranded
DNA End-Joining Repair
DNA Ligase ATP
DNA Ligases
DNA-Binding Proteins
DNA-Directed DNA Polymerase
Deoxyribonucleases
Histones
Models, Genetic
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23637284
DOI: 10.1101/cshperspect.a012757
PMCID: PMC3632057

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