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Dynamic control of strand excision during human DNA mismatch repair

7 Mar 2016

Abstract excerpt

Mismatch repair (MMR) is activated by evolutionarily conserved MutS homologs (MSH) and MutL homologs (MLH/PMS). MSH recognizes mismatched nucleotides and form extremely stable sliding clamps that may be bound by MLH/PMS to ultimately authorize strand-specific excision starting at a distant 3'- or 5'-DNA scission. The mechanical processes associated with a complete MMR reaction remain enigmatic. The purified human...

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PMID: 26951673
DOI: 10.1073/pnas.1523748113

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