Understanding and re-engineering nucleoprotein machines to cure human disease.

doi:10.2217/17435889.3.1.93

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Article

Understanding and re-engineering nucleoprotein machines to cure human disease.

Nanomedicine (London, England) - 1 Feb 2008

Dynan William, Takeda Yoshihiko, Roth David, Bao Gang

Abstract excerpt

The mammalian nucleus is filled with self-organizing, nanometer-scale nucleoprotein machines that carry out DNA replication, RNA biogenesis and DNA repair. We discuss, as a model, the nonhomologous end-joining (NHEJ) machine, which repairs DNA double-strand breaks. The NHEJ machine consists of six core polypeptides and 10-20 ancillary polypeptides. A full understanding of its design principles will require...

Topics

Gene Targeting
Genetic Predisposition to Disease
Genetic Therapy
Humans
Models, Genetic
Nucleoproteins
Protein Engineering

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Identifiers

PMID: 18393669
DOI: 10.2217/17435889.3.1.93
PMCID: PMC2766608

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