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DNA End Resection: Facts and Mechanisms

27 May 2016

Abstract excerpt

DNA double-strand breaks (DSBs), which arise following exposure to a number of endogenous and exogenous agents, can be repaired by either the homologous recombination (HR) or non-homologous end-joining (NHEJ) pathways in eukaryotic cells. A vital step in HR repair is DNA end resection, which generates a long 3' single-stranded DNA (ssDNA) tail that can invade the homologous DNA strand. The generation of 3' ssDNA...

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Identifiers

PMID: 27240470
DOI: 10.1016/j.gpb.2016.05.002

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