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Article

Structure of a NHEJ polymerase-mediated DNA synaptic complex.

Science (New York, N.Y.) - 19 Oct 2007

Brissett Nigel C, Pitcher Robert S, Juarez Raquel, Picher Angel J, Green Andrew J, Dafforn Timothy R, Fox Gavin C, Blanco Luis, Doherty Aidan J

Abstract excerpt

Nonhomologous end joining (NHEJ) is a critical DNA double-strand break (DSB) repair pathway required to maintain genome stability. Many prokaryotes possess a minimalist NHEJ apparatus required to repair DSBs during stationary phase, composed of two conserved core proteins, Ku and ligase D (LigD). The crystal structure of Mycobacterium tuberculosis polymerase domain of LigD mediating the synapsis of two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17947582
DOI: 10.1126/science.1145112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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