Article

DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signaling

2020-07-01

Abstract excerpt

Abstract A DNA double-strand break (DSB) is considered the most critical DNA lesion because it causes cell death and severe mutations if it is not repaired or repaired incorrectly. Accumulating evidence has shown that the majority of DSBs are repaired by DNA non-homologous end joining (NHEJ), the first utilized repair pathway in human cells. In contrast, the repair pathway is sometimes diverted into using homologo...

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Literature Corpus work: 2ee97ad7-d96b-50e2-a6e6-3ebffcbfdf6d
DOI: 10.1007/s42764-020-00017-8

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