Article

Sequential division of labor between PAXX and XLF drives NHEJ synaptic complex stability and maturation

2026-08-12

Abstract excerpt

DNA double-strand breaks (DSBs) are primarily repaired by non-homologous end joining (NHEJ), which tethers and ligates DNA ends within a synaptic complex. PAXX is an NHEJ accessory factor related to XRCC4 and XLF, but its mechanistic role and genetic interaction with XLF are unclear. Using biochemical assays and single-molecule imaging within Xenopus laevis egg extracts and human cell assays, we show that PAXX bri...

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Literature Corpus work: 028c337a-7166-5ac1-9f5e-cd871567a5a2
DOI: 10.64898/2026.08.10.743781

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