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How to fix DNA breaks: new insights into the mechanism of non-homologous end joining

3 Oct 2023

Abstract excerpt

Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation-induced DNA double-strand breaks (DSBs) in human cells and is essential for the generation of mature T and B cells in the adaptive immune system via the process of V(D)J recombination. Here, we review how recently determined structures shed light on how NHEJ complexes function at DNA DSBs, emphasizing how multiple...

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PMID: 37787023
DOI: 10.1042/bst20220741

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