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The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

7 Jun 2010

Abstract excerpt

Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). The various causes of double-strand breaks (DSBs) result in a diverse chemistry of DNA ends that must be repaired. Across NHEJ evolution, the enzymes of the NHEJ pathway exhibit a remarkable degree of structural tolerance in...

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PMID: 20192759
DOI: 10.1146/annurev.biochem.052308.093131

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