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The spatial organization of non-homologous end joining: From bridging to end joining

11 Mar 2014

Abstract excerpt

Non-homologous end joining (NHEJ) repairs DNA double-strand breaks generated by DNA damage and also those occurring in V(D)J recombination in immunoglobulin and T cell receptor production in the immune system. In NHEJ DNA-PKcs assembles with Ku heterodimer on the DNA ends at double-strand breaks, in order to bring the broken ends together and to assemble other proteins, including DNA ligase IV (LigIV), required...

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PMID: 24636752
DOI: 10.1016/j.dnarep.2014.02.010

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