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Article

Single-Strand Break End Resection in Genome Integrity: Mechanism and Regulation by APE2

14 Aug 2018

Abstract excerpt

DNA single-strand breaks (SSBs) occur more than 10,000 times per mammalian cell each day, representing the most common type of DNA damage. Unrepaired SSBs compromise DNA replication and transcription programs, leading to genome instability. Unrepaired SSBs are associated with diseases such as cancer and neurodegenerative disorders. Although canonical SSB repair pathway is activated to repair most SSBs, it remains...

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PMID: 30110897
DOI: 10.3390/ijms19082389

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