Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutations: recent advances in brain aging and neurodegeneration.

Current opinion in genetics & development - 1 Oct 2026

Oatman Stephanie R, Huang August Y, Miller Michael B

Abstract excerpt

Somatic mutations are genetic variants that occur after the single-cell phase of development and have been implicated in disease pathogenesis. While most DNA lesions are detected and repaired, examination of healthy tissue has revealed that some lesions escape repair, leading to somatic mutations that accumulate at a consistent rate, including in human brain tissue and postmitotic neurons. Emerging methodological...

Read the complete abstract on PubMed

Topics

Humans
Neurodegenerative Diseases
Aging
Brain
Mutation
Animals
Neurons

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutagenesis

Source

Identifiers

PMID: 42537587
DOI: 10.1016/j.gde.2026.102519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutations: recent advances in brain aging and neurodegeneration.PMID 42537587Read ↗

Brain Somatic Mutation in Aging and Alzheimer's Disease.Semantic proximity Read ↗

Somatic mutations in aging and disease.Semantic proximity Read ↗

Mitigating age-related somatic mutation burden.Semantic proximity Read ↗

Challenges of proving a causal role of somatic mutations in the aging process.Semantic proximity Read ↗

Somatic mutations and genome mosaicism in aging and disease.Semantic proximity Read ↗

Somatic Mutagenesis in Mammals and Its Implications for Human Disease and Aging.Semantic proximity Read ↗

Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brainSemantic proximity Read ↗

Somatic mutations in aging, cancer and neurodegeneration.Semantic proximity Read ↗

Ageing: Somatic mutations accumulate in ageing and diseased neurons.Semantic proximity Read ↗

Somatic mutation burden in relation to aging and functional life span: implications for cellular reprogramming and rejuvenation.Semantic proximity Read ↗

Somatic mutations, genome mosaicism, cancer and aging.Semantic proximity Read ↗

Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.