Article

Single-cell transcriptomic and genomic changes in the aging human brain

2023-11-07

Abstract excerpt

Aging brings dysregulation of various processes across organs and tissues, often stemming from stochastic damage to individual cells over time. Here, we used a combination of single-nucleus RNA-sequencing and single-cell whole-genome sequencing to identify transcriptomic and genomic changes in the prefrontal cortex of the human brain across life span, from infancy to centenarian. We identified infant-specific cell...

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Literature Corpus work: e5b9c68a-595e-5c86-b857-a8e15fe3ece1
DOI: 10.1101/2023.11.07.566050

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