Article

The <i>Saccharomyces cerevisiae</i> Hrq1 and Pif1 DNA helicases synergistically modulate telomerase activity <i>in vitro</i>

2018-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Telomere length homeostasis is vital to maintaining genomic stability and is regulated by multiple factors, including telomerase activity and DNA helicases. The Saccharomyces cerevisiae Pif1 helicase was the first discovered catalytic inhibitor of telomerase, but recent experimental evidence suggests that Hrq1, the yeast homolog of the disease-linked human RecQ-like helicase 4 (RECQL4), plays a...

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Literature Corpus work: b0cb892e-c5b6-5412-8b71-0bae925d22be
DOI: 10.1101/327320

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