Article

DNA binding contributes to dominant-negative effects of a catalytically inactive RecQ4-family helicase

2026-02-15

Abstract excerpt

<h4>ABSTRACT</h4> DNA inter-strand crosslinks (ICLs) are highly cytotoxic lesions that require coordinated processing for repair. The RecQ4-family helicase Hrq1 promotes ICL repair in Saccharomyces cerevisiae , yet the mechanistic basis of its function remains unclear. Notably, the catalytically inactive hrq1-K318A allele confers greater sensitivity to ICL-inducing agents than deletion of HRQ1 , suggesting a d...

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Literature Corpus work: 697196ac-79f9-5291-9dfa-19767e669af7
DOI: 10.64898/2026.02.13.705743

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