Article

A screen for synthetic genetic interactions with the Saccharomyces cerevisiae hrq1ΔN allele

2025-07-06

Abstract excerpt

The Saccharomyces cerevisiae Hrq1 helicase is a functional homolog of the disease-linked human RECQL4 enzyme and has been used as a model to study RecQ4 helicase subfamily biology. Although the motor cores of Hrq1 and RECQL4 are quite similar, these proteins display distinct N-terminal domains (NTDs) of unknown function. Do these domains facilitate species-specific activities by the two helicases, or do they serv...

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Literature Corpus work: f3525062-3f8e-5ff1-aa36-f75d7d104000
DOI: 10.1101/2025.07.03.663020

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