Article
Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres.
Molecular cell - 13 Mar 2009
Rog Ofer, Miller Kyle M, Ferreira Miguel Godinho, Cooper Julia Promisel
Abstract excerpt
Genome stability depends upon the RecQ helicases, which are conserved from bacteria to man, but little is known about how their myriad activities are regulated. Fission yeast lacking the telomere protein Taz1 (mammalian TRF1/TRF2 ortholog) lose many hallmarks of telomeres, including accurate replication and local protection from DNA repair reactions. Here we show that the RecQ homolog, Rqh1, is sumoylated....
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