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Article

The human Rap1 protein complex and modulation of telomere length.

The Journal of biological chemistry - 2 Jul 2004

O'Connor Matthew S, Safari Amin, Liu Dan, Qin Jun, Songyang Zhou

Abstract excerpt

Proper maintenance of telomere length and structure is necessary for normal proliferation of mammalian cells. Mammalian telomere length is regulated by a number of proteins including human repressor activator protein (hRap1), a known association factor of TRF2. To further delineate hRap1 function and its associated proteins, we affinity-purified and identified the hRap1 protein complex through mass spectrometry...

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Source

Identifiers

PMID: 15100233
DOI: 10.1074/jbc.M312913200

Genes

PARP1
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The human Rap1 protein complex and modulation of telomere length.PMID 15100233Read ↗

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusionsSemantic proximity Read ↗

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Rap1 affects the length and heterogeneity of human telomeres.Semantic proximity Read ↗

Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the TelomereSemantic proximity Read ↗

Human RAP1 specifically protects telomeres of senescent cells from DNA damageSemantic proximity Read ↗

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.Semantic proximity Read ↗

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.Semantic proximity Read ↗

TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length RegulationSemantic proximity Read ↗

A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.Semantic proximity Read ↗

Human RAP1 inhibits non‐homologous end joining at telomeresSemantic proximity Read ↗

Yeast Rap1 contributes to genomic integrity by activating DNA damage repair genes.Semantic proximity Read ↗

Human Rap1 modulates TRF2 attraction to telomeric DNASemantic proximity Read ↗

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